Signs and Symptoms of Wison Disease

Wilson disease first attacks the liver and the central nervous system or both at a time. It is caused due to excessive deposition of copper in the liver. Liver failure occurs rarely though.

Signs and Symptoms of Wilson Disease

The following are the symptoms that accompany the this chronic liver disease:

  • Painful swelling of the liver or spleen
  • Yellowing of the skin
  • Whitening of the eyes
  • Oedema ( fluid accumulation) in legs, abdomen
  • Vulnerable to bruising
  • Severe Chronic fatigue

Neurological Symptoms of Wilson Disease

Copper gets build up in the central nervous system. The following are the neurological symptoms of Wilson disease which occur due to the deposition of copper of central nervous system:

  • Problem in swallowing
  • Deterioration of speech
  • Reduced physical coordination
  • Ballistic movements (unintentional and uncontrolled)
  • Unintentional tremors
  • Stiffness and rigidity of muscles
  • Changes in the behavioural pattern

Other Signs and Symptoms of Wilson Disease

Other prominent symptoms of Wilson disease include the following:

  • Anaemia
  • Low plate let and white blood cell count
  • Delayed blood clotting
  • High levels of proteins, amino acids uric acid in the urine
  • Premature osteoporosis and arthritis

Unique Feature of Wilsons Disease

Kayser-Fleischer rings (rings result from a build up of copper in the eyes ) form the most characteristic feature of the Wilson disease. These rigs appear around edge of the iris (coloured part of the eye surrounding the pupil) and in the rim of the cornea (transparent outer membrane that covers the eye).

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