Menetrier's Disease – Causes of Menetrier's Disease, Symptoms of Manetrier's Disease

Menetrier’s disease

is a pathological condition of the stomach where its tissue wall is affected. It causes enlargement of the ridges along the inside stomach wall, called rugae. This forms giant folds in the lining of the stomach. Let us know more about this disease in this article.

What happens during Manetrier’s disease?

In this disease, giant folds of tissue grows in the wall of the stomach. The functional tissue of the stomach is inflamed. It causes glands in the stomach to waste away. This makes body lose fluid containing


(an essential protein). The person with this disease has increased risk of stomach cancer.

This disease is more common in men with high incidence in age range of

30 and 60.

It is quite a rare disease of stomach, also known by the names protein losing gasteropathy, gaint hypertrophic gastritis and hypertrophic gastropathy.

Causes of Manetrier’s Disease

It is yet not clear what causes Manetrier’s disease. Experts think it to be an acquired disorder, though there is no genetic component connected to the disease.

Recent studies have revealed that the disease is seen in those stomachs which make abnormally high amounts of a protein called

transforming growth factor-alpha

(TGF-aplha). This growth factor protein is responsible for increase in the size and number of the stomach cells. But what causes this high amounts of TGF-alpha is yet not known.

Symptoms of Manetrier’s Disease

Here are a few symptoms experienced by a person who has attacks of Manetrier’s disease:

  • Nausea
  • Frequent vomiting
  • Severe pain in the top middle part of the abdomen
  • swelling of the face, limbs, abdomen, and feet
  • Loss of appetite
  • Extreme weight loss
  • Malnutrition
  • Anemia
  • Low blood protein
  • Diarrhea

You can get more information about diagnosis and treatment of Menetrier’s disease in a related article in this site.

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