Menetrier's Disease – Diagnosis and Treatment of Menetrier's Disease

Menetrier’s disease

is a condition wherein the tissue wall of the stomach is abnormally enlarged. The ridges along the inside of the stomach wall, called rugae, are distended in this disease. As a result, giant folds are formed in the linings of the stomach.

Manetrier’s disease causes the glands in stomach to waste away. The body loses an essential protein called albumin, in the course of this disease. It is quite a rare disease of stomach, also known by the names protein losing gasteropathy, gaint hypertrophic gastritis and hypertrophic gastropathy.

In this article we discuss how Menetrier’s disease is diagnosed and treated.

Diagnosis of Manetrier’s Disease:

The disease is diagnosed by


X-ray of the stomach is the first step of diagnosis.


Endoscopy is a procedure to look at the inside of the stomach using a long, lighted tube through the mouth. During this procedure, a small piece of stomach tissue is removed with accessory tools provided to examine it under the microscope. The procedure is called biopsy.

Treatment of Manetrier’s Disease

First approach for treatment is to relieve nausea and pain. A doctor may prescribed appropriate medications for it, considering the age of the patient and severity of the disease.

The doctor may also prescribe a high protein diet to balance the loss of proteins from enlarged rugae.


may be needed in severe cases following the death of stomach tissue. It may involve removal of a part of complete stomach.

Recently an anticancer drug called


(Erbitux) is investigated as a promising drug for the condition which blocks the action of transforming growth factor-alpha (TGF-aplha).

You can get more information about the causes and symptoms of Menetrier’s disease in a related article in this site.

Leave a reply

Your email address will not be published. Required fields are marked *